A glance through the history books has identified some of the most successful - and unsuccessful - pick numbers in the draft.
Unsurprisingly, the majority of the top 10 selections have yielded long-term careers, with the prized Pick 1 seeing an average of 160.8 games per player across the past 40 drafts.
It is the assumption that the earlier a player is selected on draft night, the more talent and potential they have.
However, we know that this isn't always the case.
Some highly-touted juniors have been deemed "busts" for not living up to the hype of their draft selection, while on the other end of the spectrum, diamonds can be found in the rough.
So, for those who are superstitious out there, which pick would you rather go?
Below, we decipher the ideal pick and the selections which players should hope to avoid...
As mentioned, the first selection, albeit fielding much more scrutiny and pressure for being the first cab off the rank, results in the largest games per individual on average.
A staggering 160 matches equate to eight more-than-solid home and away seasons or sometimes less dependent on the prospect.
The number is heightened by the likes of Luke Hodge (346 games), Brendon Goddard (334 games) and Marc Murphy (300), while nine other players have hit 200 or more games.
Understandably, Picks 2, 3, 4, 5, 7, 8 and 9 follow closely after, with all selections resulting in at least 105 games per player.
In most, if not all, drafts there always ends up being a few diamonds in the rough.
Through a raft of circumstances - regarding development, club necessity or injury - that see individuals slip through the cracks, some picks appear to be more successful than others.
Seemingly, three selections have been identified as winners in comparison to the rest of the draft - Picks 37, 40 and 56.
Pick 40 leads the trio with an average of 92.5 games, helped on by father-son stars Gary Ablett Jnr, Jobe Watson and Josh P. Kennedy.
Sydney's Luke Parker was also a steal at that selection, while Mitch Robinson and Chris Mayne played at the elite level for at least a decade.
Alex Neal-Bullen and Tom Stewart are currently maintaining the legacy of the treasured selection.
Pick 37 is next with an average of 90.4 games, forged by former North Melbourne pair Todd Goldstein and Scott Thompson.
St Kilda star Leigh Montagna added 287 matches to his name, and West Coast's Mark LeCras terrorised defenders for 219 matches.
Fremantle captain Alex Pearce is doing the selection proud in the modern-day, rising to heights his pick wouldn't ordinarily suggest.
Lastly, and surprisingly, is Pick 56, which has produced a handful of stars since 1990.
Key forwards Daniel Bradshaw and Cameron Mooney were taken late on their respective draft nights but proved their doubters wrong.
As did Ryan O'Keefe, Daniel Cross and Joel Patfull, lasting over a decade in the AFL.
Currently, Hawthorn captain James Sicily is continuing the staggering trend of Pick 56 resulting in stars of the competition.
In football, as in life, what goes up must come down.
A unique illustration of the unintended equilibrium of our great game is the fact that Pick 6 sits shockingly low on the totem pole despite its esteem.
The sixth selection over the past four decades has struggled in comparison to its surrounding counterparts, yielding a measly 69.4 games on average per player.
Since 1981, only three players - out of 40 - have reached 200 or more games.
Jack Macrae, Gary Rohan and Chad Wingard were the saviours of the selection, which will cop a further whack in 12 months' time due to the latter pair being delisted and retiring respectively.
Former Pick 6 selections Jaidyn Stephenson and Sam Petrevski-Seton both ended their career early in the piece, while Adelaide's Fischer McAsey unfortunately never reached that next level.
Gold Coast's Ben King would be a lot further into his career but faced long-term knee injuries, limiting him to 95 matches in seven years.
Whilst selections have some merit behind their history, some are just outlandish, albeit from a much smaller sample size.
Rookie selection Pick 93 has an average of 208 games (and counting) due to the efforts of Sydney veteran Harry Cunningham. He is the sole occupier of the selection.
National draft Pick 105 also has a staggering 133.5 games average, mainly thanks to Western Bulldogs champion Chris Grant (341 matches).