Carlton announced forward Harry McKay's injury fate, on Monday revealing he will miss the remainder of the home and away season, while midfielder Adam Cerra is battling an injury concern of his own.
McKay is set to undergo an arthroscope on his knee, sidelining the important key forward for 6-8 weeks as the Blues continue their finals assault.
The 25-year-old McKay will undergo the arthroscope procedure this week before commencing a rehabilitation period.
"While it is disappointing for Harry that he will be sidelined, we know he will be the ultimate professional and continue to have a positive influence around the club during this period of the season," Carlton football boss Brad Lloyd said in a club statement on Monday.
"One of the main things the playing group prides itself on is stepping up and everyone playing their role when needed. That opportunity will present again in Harry's absence.
"We'll continue to lean on our even contribution across the board as we lock in for this Saturday's game against West Coast."
Cerra, meanwhile, is nursing a tight hamstring and is a test to play this weekend against the Eagles.
The Blues are scheduled to play the West Coast Eagles, Collingwood, St Kilda, Melbourne, the Gold Coast Suns, and the GWSGiants in their last six home and away matchups.