Hamstring and concussion concerns forced Collingwood into playing with just three on the bench in the second half of Saturday's match against Kuwarna (Adelaide).
The Magpies made their tactical sub change following the main break with forward Will Hoskin-Elliott unable to continue in the match due to a hamstring injury.
The reigning premiers confirmed the change at the start of the third term, with Harvey Harrison brought into the game as a result of Hoskin-Elliott's setback.
Collingwood's injury concerns were compounded later into the quarter after spearhead Reef McInnes was ruled out from returning to the game due to concussion.
McInnes copped a knee to the back of the head when competing for the ball at ground level and eventually made his way from the field for a concussion test, which was subsequently failed by the 21-year-old.
McInnes will at least miss his side's Round 11 clash with Fremantle as he enters the AFL's mandatory 12-day concussion protocols.
"Reef's got concussion, so he's going to be out for a period of time," coach Craig McRae confirmed after the win.
"Will's got a low-grade hamstring (strain), which we'll know more tomorrow how bad that is. But it's been reported as a low-grade hamstring."
Defender Isaac Quaynor suffered a suspected lower leg injury in the second term but has been able to play out the game.
Collingwood's injury woes could be eased over the coming weeks as Tom Mitchell (foot), Beau McCreery (concussion), Brody Mihocek (hamstring) and Jack Bytel (concussion) potentially return for the Dockers game.
Adelaide also made their sub change during the third term, with Lachie Sholl replaced by Ned McHenry for tactical purposes.
