Carlton was dealt a double injury blow in the first quarter in their game against Melbourne.
David Cuningham landed heavily on his knee a minute into the first quarter and was substituted out of the game.
He was replaced by medical sub-Michael Gibbons and will be assessed to determine if he has suffered an ACL injury.
Key forward Harry Mckay spent most of the first quarter on the bench after injuring his shoulder in a marking contest.
There were fears he would also be ruled out of the game but returned to the field in the second term, albeit without his usual impact.
McKay leads the Coleman Medal with 30 goals, ahead of Taylor Walker and Josh Bruce.