West Coast key forward Jake Waterman will miss Saturday's clash against St Kilda due to soreness with his iliotibial band (ITB) near his knee.
Waterman has been a revelation in 2024, kicking 41 goals in 15 outings as the Eagles' main target up forward.
However, the club will need to rely on co-captain Oscar Allen while looking to recall veteran Jack Darling to help fill the void.
Waterman will be sidelined alongside co-captain Liam Duggan, who suffered a concussion on the back of a gruesome Charlie Cameron tackle that stuck him with a three-match suspension.
Duggan has entered the mandatory concussion protocols and will miss action for at least the next week.
Small forward Tyler Brockman is also in doubt to face the Saints after injuring his ankle in the loss to Brisbane.
However, interim coach Jarrad Schofield could bring in Jack Petruccelle and Dom Sheed, with the latter performing impressively in the WAFL alongside Darling over the weekend.
“Duggan and Brockman are out," Schofield confirmed.
"We are still finalising things and we will look into Petch and Jai Culley coming into the side.
"Jake Waterman will have a week off.”
AFL emergency Jai Culley is also a sniff to regain his spot in the senior side following a dominant performance at the reserves level.
Intercept defender Jeremy McGovern was ruled out earlier in the week.