North Melbourne could unleash as many as five debutants in their one Round 1 against Port Adelaide on Sunday afternoon.

Kangaroos coach David Noble confirmed new recruits Aidan Corr, Jaidyn Stephenson and Lachie Young will all make their debuts for their new club after being acquired during the trade period.

He also admitted that the club could hand one or two players their AFL debuts.

"They'll all play." Noble told reporters.

"It's great for those guys. The club worked hard to get those guys through the trade period and they've all displayed some really good traits in the areas they've played in."

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Draftees Tom Powell and Charlie Lazzaro have impressed during the pre-season and could also be in line for a debut, while Will Phillips and Phoenix Spicer may also get their chance.

Powell, 19, was selected with Pick 13 in the 2020 AFL draft by the Kangaroos after averaging 35 disposals a game for the Double Blues in the SANFL Under-18 competition.

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Lazzaro, 18, was taken with Pick 36 by the Roos in the 2020 draft and has shown explosive ability during the pre-season that could also give him an opportunity.

Noble also confirmed that star midfielder Ben Cunnington will be unavailable for Round 1 due to conditioning.

"Ben Cunnington wonโ€™t be available." Noble added.

"Heโ€™s in the clear with concussion symptoms, but itโ€™s more about reloading."

North Melbourne and Port Adelaide will face-off at 1:10pm on Sunday afternoon at Marvel Stadium AEDT.