Star Richmond duo Dustin Martin and Jacob Hopper have been ruled out of the Tigers' crucial bout with Collingwood this Friday night.
Martin was substituted out of Richmond's win over the Adelaide Crows last Saturday, with it later revealed that was decided due to the Brownlow medallist's hamstring injury history, despite the Tigers on Wednesday declaring he would miss because of "general soreness".
Hopper, meanwhile, will miss due to a knee concern, after the ex-Giant's leg was twisted awkwardly in a tackle last weekend.
Martin and Hopper join defender-turned-midfielder Jayden Short in being rubbed out of contention for the game, as he was ruled out of Friday's clash earlier in the week as a result of a calf complaint that originated in the pre-season.
Also absent for Richmond in Round 3 will be defender Nathan Broad after he was dished a four-game suspension on Tuesday for concussing Crow Patrick Parnell in a sling tackle.
Meantime, Collingwood's main injury concern appears to be forward Brody Mihocek, who is nursing a finger ailment and is in some doubt to face Richmond.
Livewire Magpies forward Jack Ginnivan has served his two-match suspension, however, coach Craig McRae on Wednesday confirmed the 20-year-old will make his footballing return via Collingwood's VFL side this weekend.
The Tigers are scheduled to battle the Pies on Friday, March 31 (7:50 PM AEDT) at the MCG.